Small Wonders: The Antibodies From Camels And Sharks That Could Change Medicine

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Small Wonders: The Antibodies From Camels And Sharks That Could Change Medicine
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A handful of animals make a pared-down version of these pathogen-fighting proteins of our immune system. Scientists hope to harness them as treatments for ills from cancer to Covid, for tracking cells in the body, and more.

Camels, llamas, alpacas, sharks, rays and their relatives make unusual antibodies that researchers are investigating for studying — and fighting — human diseases.Every four months, pathologist Aaron LeBeau scoops into a net one of the five nurse sharks he keeps in his University of Wisconsin lab. Then he carefully administers a shot to the animal, much like a pediatrician giving a kid a vaccine.

“They can get into little nooks and crannies of different proteins that human antibodies cannot access,” LeBeau says. Human blood seemed too risky to work with, given concerns at the time about potential HIV exposure, and the students didn’t want to kill a mouse. But the students’ professor, the late Raymond Hamers, happened to be studying sleeping sickness in large animals. He gave the students some blood from a camel, says immunologist Serge Muyldermans, who was then a post-doctoral researcher at the university.

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