Science, Space and Technology News 2024
UC Davis scientists found that Salmonella uses electric signals in the gut to invade the body, a process called galvanotaxis, offering new insights into bacterial infections and potential treatments for diseases like IBD.This question is fundamental for infectious disease experts and people who study bacteria. Harmful pathogens, like Salmonella, find their way through a complex gut system where they are vastly outnumbered by good microbes and immune cells.
FAE, on the other hand, contains M cells overlying small clusters of lymphatic tissue known as Peyer’s patches. These M cells are tasked with antigen sampling. They act as the immune system’s first line of defense against microbial and dietary antigens.The research that was done on a mouse model showed that Salmonellae detect electric signals in FAE. They move toward this part of the gut where they find openings through which they can enter.
The study also showed that E. coli and Salmonella respond differently to bioelectric fields. They have opposite responses to the same electric cue. While E. coli clustered next to the villi, Salmonella gathered to FAE.“Notably, the bioelectric field in the gut epithelia is configured in a way that Salmonellae take advantage of to be sorted to the FAE and less so for E. coli,” explained Sun. “The pathogen seems to prefer the FAE as a gateway to invade the host and cause infections.
“Our study presents an alternative or a complementary mechanism in modulating Salmonella targeting to the gut epithelium,” Zhao said.The study might have the potential to explain complex chronic diseases, such as inflammatory bowel disease .
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