Nature research paper: Self-patterning of human stem cells into post-implantation lineages
Investigating human development is a significant scientific challenge due to the technical and ethical limitations of working with embryonic samples. In the face of these difficulties, stem cells have provided an alternative to experimentally model inaccessible stages of human development.
Importantly, our system reproducibly captures spontaneous differentiation and co-development of embryonic epiblast and extra-embryonic hypoblast-like lineages, establishes key signalling hubs with secreted modulators, and can undergo symmetry breaking-like events.
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