Science, Space and Technology News 2024
New research highlights the anti-aging benefits of vitamin D and its receptor in Drosophila, revealing their significant role in stem cell health and longevity, and providing insights into aging mechanisms.
Adult stem cells play a crucial role in keeping tissue balance, with their diminished functionality tied to aging and related illnesses, affected by the surrounding cells’ environment. Clinical studies in humans have consistently shown a decrease in vitamin D and its receptor levels due to aging and cancer. Despite this, the ways in which the vitamin D/vitamin D receptor pathway aids in anti-aging and life span extension remain unclear.
In a new study, researchers Joung-Sun Park, Hyun-Jin Na, and Yung-Jin Kim from Pusan National University and Korea Food Research Institute aimed to determine the protective role of the vitamin D/vitamin D receptor pathway in differentiated enterocytes during intestinal stem cell aging. Inhibitory effect of VitD on age- and oxidative stress-related accumulation of supernumerary centrosomes in midgut ISCs. Credit: 2024 Park et al.The researchers stated, “This study aimed to determine the protective role of VitD/VDR in differentiated ECs during ISC aging using the adultmidgut model for stem cell aging biology, the researchers revealed that vitamin D receptor knockdown in ECs induced ISC proliferation, EC death, ISC aging, and enteroendocrine cell differentiation.
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