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The Texas A&M University research team behind it believes similar results could be seen in people, with further research and development.The mice were 18 months old, an age commonly treated as older adulthood in mouse studies, roughly comparable to humans in their late 50s to late 60s.
"As we develop and scale this therapy, a simple, two-dose nasal spray could one day replace invasive, risky procedures or maybe even months of medication,"brain's immune cellsIn the study, 18-month-old male and female mice received two intranasal doses, spaced two weeks apart. Delivering the treatment through the nose may help EVs reach the brain more directly without invasive surgical procedures, and the researchers report that they were quickly absorbed. After the two doses, the treated animals outperformed control mice on tasks measuring object recognition and spatial memory. Further biochemical analysis of the hippocampus suggested the treatment had the desired effects on brain inflammation., tiny pieces of genetic code that regulate gene expression. As these microRNAs are released, they rewire brain cells to turn off or dial down some of the alarm signaling that drives neuroinflammaging. "We are giving neurons their spark back by reducing oxidative stress and reactivating the brain's mitochondria."a million a year by 2060, double the current level, and this study points to a possible new way to reduce age-related neuroinflammation that can spark dementia.age more healthily "We're aiming for successful brain aging: keeping people engaged, alert, and connected. Not just living longer, but living smarter and healthier."
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