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White could be the new beige when it comes to fat cells, following the discovery of a switch that maintains the functions of adipose tissue in mice, transforming it from a lipid-locker into a calorie-burner.
By depriving the mice of the transcription factor Klf15, the researchers were able to transform the identity of 'deep storage' white adipose tissue into a more transient, thermoregulating form called Brown fat, on the other hand, is darkened by a generous number of cellular power-generators primed to burn through its fuel supply at a moment's notice. Scarce in adult humans, babies (For most of our evolutionary history this age-relative balance of WAT versus BAT has served us well. Mature members of our species keep warm by using fat as a fuel for movement, while immobile newborns benefit from a more passive form of temperature regulation.
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