A big leap forward in activating insulin production in targeted genes through new development – direct current (DC)-actuated regulation technology (DART) could help treat diabetes.
The goals of both the 2020 and 2023 studies were to return mice blood glucose levels to acceptable levels.
The researchers used electrically stimulating acupuncture needles which stimulated insulin release and restored normoglycemia . The researchers claim that as the DART system does not need hours at higher voltages but only seconds at lower voltages to actuate transgene expression, it has higher energy efficiency and safety.
The study also noted that electronics-free direct battery-powered low-voltage DC control of therapeutic transgenes in human cells is a leap forward. It represented the missing link that will enable wearables to control genes in the not-so-distant future.
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