In a groundbreaking experiment, researchers have brought a mouse to life with the help of a single-celled organism that existed long before any multicellular animals walked the earth.
Genetic research has advanced dramatically in recent years, progressing from enhancing food crops through genetic insights to exploring the possibility of resurrecting extinct species.Today, scientists from The University of Hong Kong and Queen Mary University of London have accomplished what was once unthinkable: creating mouse stem cells—and ultimately a living mouse—without using any mouse DNA.
These genes enable complex cellular processes, such as gene regulation and DNA binding, which are critical for multicellular development. While choanoflagellates do not possess stem cells, their Sox genes likely evolved to manage basic cellular functions.Over time, these mechanisms were co-opted by multicellular organisms to facilitate the development of specialized cells and tissues.
The study highlights how ancient genes shared across species can serve fundamental roles despite vast evolutionary distances. The Sox and POU genes from choanoflagellates, separated from mice by nearly a billion years of evolution, retain the ability to drive pluripotency. This discovery underscores the deep genetic continuity that links all life on Earth.Understanding how ancient transcription factors drive pluripotency could lead to novel approaches in regenerative medicine.
Cloning DNA Choanoflagellate Mouse Shinya Yamanaka Woolly Mammoth Tasmanian Tiger Bring Back Extinct Animals
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