The Buffalo Bills are set to host the San Francisco 49ers in a win-and-in game for the home team.
series is dedicated to breaking down how the Buffalo Bills match up with their opponent in every game of the 2024 NFL season. This series will look at five key matchups: Bills Pass Offense vs. Opponent Pass Defense, Bills Rush Offense vs. Opponent Rush Defense, Bills Pass Defense vs. Opponent Pass Offense, Bills Rush Defense vs. Opponent Rush Offense, and Bills Special Teams vs. Opponent Special Teams.
At 5-6, the 49ers are in full desperation mode but have a pass defense that has shown the ability to dominate this season. Coming into this game, they rank third in Pass Defense DVOA while giving up just 13 pass touchdowns and forcing 11 interceptions. The key to their success against the pass is a secondary that features a dynamic trio of playmakers in Deommodore Lenoir , Ji’Ayir Brown , and Malik Mustapha .
Those vulnerabilities will be further exacerbated by an offensive line for Buffalo that leans on their athleticism to create holes for their runners to attack. In particular, Dion Dawkins , Spencer Brown , and Connor McGovern have all shown a propensity to win in space and dominate second-level defenders. This week those abilities could be on display further due to San Francisco’s struggles in the interior of their defensive line.
This week, though, Buffalo may have its hands full as San Francisco seems prepared to lean into the run in a game that could be heavily affected by the weather. Christian McCaffrey will play in his fourth game this season, and while he hasn’t looked like his pre-injured self yet. it feels like only a matter of time until he rounds back into the best running back in the NFL.
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