Evidence suggests that exercise creates a molecular profile in muscle that is consistent with the expression of youthful-promoting Yamanaka factors. A recent study published in the Journal of Physiology has further supported the idea that exercise can help maintain youthful qualities in aging org
) that can revert highly specified cells back to a stem cell, which is a younger and more adaptable state. The Nobel Prize in Physiology or Medicine was awarded to Dr. Shinya Yamanaka for this discovery in 2012. In the correct dosages, inducing the Yamanaka factors throughout the body in rodents can ameliorate the hallmarks of aging by mimicking the adaptability that is common to more youthful cells.
Ultimately, the team determined that exercise promotes a molecular profile consistent with epigenetic partial programming. That is to say: exercise can mimic aspects of the molecular profile of muscles that have been exposed to Yamanaka factors . This beneficial effect of exercise may in part be attributed to the specific actions of Myc in muscle.
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