A team led by Prof. Guang Shouhong and Prof. Feng Xuezhu from the University of Science and Technology (USTC) of the Chinese Academy of Sciences (CAS) revealed, for the first time, the composition and regulatory mechanism of the nuclear vacuole in C. elegans. The study was published in Cell Reports.
, the team visualized the nucleolar structure of C. elegans. and found that there were two kinds of nucleoli: spherical and vacuole-contained nucleoli. Candidate-based RNAi screening was used and it was found that knockdown of a distinct class of ribosomal proteins of the large subunit reshaped spherical nucleoli to vacuole-contained nucleoli, accompanied by abnormal accumulation of 27SA2 rRNAs.
Another two highly conserved nucleolar proteins with internal disordered sequences, NUCL-1 and FIB-1, are also required for the formation of NoVs. Collectively, these findings imply a strong correlation between the organization of the nucleolus and the processing and maturation of rRNA. The researchers found that the appearance of NoVs is dynamic in C. elegans, which means the presence of NoVs varies in different states during development. In addition, the researchers also speculated that the expression and processing of rRNAs are differentially regulated across different cell types and throughout development and aging, which would induce the formation of cell-type-specific nucleolar structures and the change of NoVs during germline maturity and aging of the animals.
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