Autophagy is the process by which cells break down waste and gunk inside them. Find out more at 🚀 engineering interestingengineering
Suppose, If this autophagy process, for some reason, is unstable, and there’s an accumulation of junk in your cells. In that case, it may lead to neurodegenerative diseases and in some cases, even cancer.To understand the fundamental gaps in their knowledge regarding the beginning of the autophagy process, a German team of researchers took several years to produce all the proteins involved in the process.
The scientists had a breakthrough moment when they switched to insect cells as molecular helpers instead. Autophagosomes are formed within minutes when a body comes under stress from activities like endurance sports or during times of starvation. “From this point on, there is no turning back: The waste disposal is assembled and collects the cellular waste,” explains Anh Nguyen, one of the two first authors of the study now published in Molecular Cell.
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