Scientists have discovered a potential target for gastric cancers associated with Epstein-Barr Virus.
Now, scientists at The Wistar Institute have discovered a potential target for gastric cancers associated with Epstein-Barr Virus; study results were published in the journal. In the paper, Wistar's Tempera lab investigates the epigenetic characteristics of gastric cancer associated with the Epstein-Barr Virus: EBVaGC.
"What we have identified is essentially a self-destruct button within this kind of cancer, and our paper shows that we figured out how to press that self-destruct button," said Tempera."Normally, a latent virus that reactivates and starts to kill cells is a bad thing.
In EBVaGC, the cancer cells' DNA is hypermethylated: the DNA contains a high percentage of cytosine with a 5-methyl group attached to it . As a silencer of gene expression, DNA methylation allows EBV to remain latent. This methylation pattern plays a significant role in regulating the EBV latency-lysis cycle within the cancer cells.
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