This light-activation technology has potential applications in tissue engineering, regenerative medicine, and understanding how the body works. Scientists have developed light-activated SpyLigation, a method using light to activate protein functions in and outside living cells. This has potential
Microscopic 2D and 3D images of University of Washington Husky logos and a dog were made with a new chemistry technique, SpyLigation, that precisely controls when and where proteins turn on. Credit: Cole DeForest Research Group
Scientists can now use light to activate protein functions both inside and outside of living cells. The new method, called light-activated SpyLigation, can turn on proteins that are normally off to allow researchers to study and control them in more detail. This technology has potential uses in tissue engineering, regenerative medicine, and understanding how the body works., metabolizing nutrients, and fighting off infections.
As reported April 17 in the journal Nature Chemistry, a team led by Emily Ruskowitz and Brizzia Munoz-Robles from the DeForest Research Group has shown that chemically modified protein fragments can be joined together into functional wholes using brief flashes of light.
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