Inaxaplin is an oral small molecule that curbs the ill effects of gene variants linked with kidney damage carried primarily by Black individuals. The drug has shown promise in a proof-of-concept study.
nephropathy spectrum rather than as separate disease states."
People with just one copy of the G1 or G2 variant, as well as those with two copies of the wild-type G0 allele, show no evidence of an elevated risk for kidney disease. story is that the apparent genetic origin of the pathological variants occurred thousands of years ago among people living in sub-Sharan Africa who were more resistant to African trypanosomiasis, also known as African sleeping sickness, caused by an endemic parasite, the blood-feeding tsetse fly.
"Until now, there's been no reason to genotype because there was nothing to do about it," said Powe in an interview.
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