Pfizer Inc's experimental respiratory syncytial virus (RSV) vaccine was 82% effective in preventing severe infections in infants when given to expecting mothers in the second half of their pregnancy, according to trial details published on Wednesday that confirm preliminary data from the study.
are developing a single-dose antibody, nirsevimab, for RSV prevention in infants, which is also under FDA review.
Pfizer's vaccine, RSVpreF, met one of the two main goals of the late-stage study. It was nearly 82% effective in preventing severe lower respiratory tract illness, such as very low oxygen levels or need for ventilator support, in infants in the first 90 days of life. Pfizer said severe illness occurred within three months in 6 infants whose mothers received the vaccine, compared with 33 infants from the placebo group who contracted serious RSV infections. The company evaluated 3,570 infants as part of the study.
The shot was 69.4% effective in preventing severe infections in the first 180 days. Severe illness occurred within six months in 19 infants born to mothers in the vaccine group, compared with 62 infants in the placebo group.About 58,000 to 80,000 children younger than 5 years old are hospitalized due to RSV infection every year in the United States, according to government data, and infants are among those at greatest risk for severe illness.
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