When screening for dementia, incorporating standard retinal imaging into an assessment of traditional risk factors for the disease can improve detection of cognitive decline. ARVO2023
, or other forms of the cognitive decline, as well as cognitively healthy controls, and paired them with their ophthalmologic records. interpretable retinal features, such as vascular properties and the thickness of the retinal layers, along with traditional risk factorsa multi-modal fusion model combining retinal images and traditional risk factors
The models were trained on data from 36,877 patients visiting four Moorfields Eye Hospitals from 2008 to 2018 and were validated on two test datasets: 4083 patients visiting the same four hospitals and 4089 patients visiting three distinct hospitals.As measured using an area under the receiver-operator curve analysis, the researchers found that the combination of deep learning, imaging, and risk factors was the most sensitive predictor of dementia .
"Our results provide further evidence for the possible benefit of using a noninvasive retinal exam in conjunction with traditional risk factors for population-based dementia screening," Struyven said.
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