Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery.
However, our current understanding of such protein-protein interactions often lacks cellular contexts because they were usually studied in an in vitro system or in cells isolated from their tissue environment. Effective methods to investigate protein-protein interactions in a tissue-specific manner are largely missing.
To bridge this technology gap, a collaborative research team of The University of Hong Kong , led by Professor Xiang David LI from the Department of Chemistry and Professor Chaogu ZHENG from the School of Biological Sciences, both from the Faculty of Science, along with Dr Xiucong BAO from the School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, recently developed a novel chemical biology approach to label proteins from specific cells with a bifunctional amino acid probe that allows...
"This study is an excellent example of how innovative chemical labelling methods can help solve difficult biological problems," said Professor Xiang David Li. A research group has developed a novel chemical tool for elucidating protein interaction networks in cells. This tool not only facilitates the identification of a protein's interacting partners in ...
Cell Biology Biotechnology Genetics Biotechnology And Bioengineering Biology Biochemistry Research Developmental Biology
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