According to recent research, a larger number of donated hearts could potentially be used for transplantation if they are kept operational in the body for a brief period after the donor's death. The technique involves restoring regional blood flow to the heart, lungs, and abdominal organs (but no
Donated hearts play a critical role in saving the lives of individuals with severe heart disease. Heart transplants can offer a new lease on life for those with end-stage heart failure, giving them the chance to return to a normal, healthy life.
The application of this approach is hoped to raise the number of viable donated hearts by up to 30% in the future, potentially alleviating the scarcity of transplant organs. In 2021, 54 countries reported 8,409 heart transplants to the Global Observatory on Donation and Transplantation .
DCD is the donation of organs by patients who tragically have a non-survivable illness. These patients are typically unconscious in intensive care in hospital and dependent on ventilation. Detailed discussions between doctors, specialist nurses and the patient’s family take place and if the family agree to organ donation, the process starts.
DCD heart transplantation started simultaneously in Australia, followed by Belgium, The Netherlands, Spain and USA. According to the GODT, 295 DCD heart transplants were performed in these six countries in 2021. Mr Stephen Large, Consultant Cardiothoracic Surgeon at Royal Papworth Hospital and chief investigator, said: “Withdrawing life support from a patient is a difficult decision for both the families and medical staff involved and we have a duty to honour the wishes of the donor as best we can. At present, one in ten retrieved hearts is turned down, but restoring function of the heart in situ could help us ensure more donor hearts find a recipient.
The researchers say that some of the benefits from taNRP are likely thanks to the reduced amount of time the heart was not receiving oxygenated blood, known as its warm ischaemic time, when compared to direct procurement . The median average time was 16.7 minutes, significantly less than the 30 minutes associated with permanent damage to the heart cells.
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