A new therapeutic that could slow down or halt the progression of Parkinson's disease has completed Phase 1 trials with positive results. Researchers and doctors spoke about the findings.
A new drug is being tested to relieve Parkinson’s disease symptoms – and it’s reportedly showing promise. The drug is designed to slow or halt the progression of the disease in patients by targeting toxic proteins that build up in the brain, according to the study published in the journal Nature Medicine on June 20. Researchers conducted a phase 1 placebo-controlled trial of an investigational immunotherapy drug called UB-312, testing for safety, tolerability and immunogenicity .
In our phase 1 trial, we showed that UB-312 may be able to stop or even reverse the course of disease by successfully targeting aggregated alpha-synuclein.' UB-312 is given as an injection, typically via multiple doses over several months, Reese noted. 'Time and science will help us to determine if this newer approach will fare better.' During the trial, PD patients reported improved daily movement after receiving the new drug.
Two similar antibody trials of prasinezumab and cinpanemab were published in 2022 in The New England Journal of Medicine, but both of those trials failed to meet their primary outcomes.' Okun concluded that 'time and science will help us to determine if this newer approach will fare better.'
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