A new class of compounds could offer the benefits of gastric bypass surgery without surgery (reduce weight, lower blood glucose, and boost calorie burn), while avoiding the side effects of nausea and vomiting commonly associated with current weight loss and diabetes drugs. Imagine getting the ben
A new class of compounds could provide the benefits of gastric bypass surgery without the need for invasive procedures. In lab animals, these injectable compounds not only reduce weight and lower blood glucose levels but also boost calorie burn, avoiding the common side effects of nausea and vomiting associated with current weight-loss and diabetes drugs.
The researchers will present their results today at the spring meeting of the American Chemical Society . ACS Spring 2023 is a hybrid meeting being held virtually and in-person March 26–30, and features more than 10,000 presentations on a wide range of science topics.pandemic,” says Robert Doyle, Ph.D., one of the two principal investigators on the project, along with Christian Roth, M.D. “They are a massive problem, and they are projected to only get worse.
To address that drawback, various researchers have designed other treatments that interact with more than one type of gut hormone receptor. For example, Doyle’s group created a peptide that activates two receptors for PYY, as well as the receptor for GLP-1. Dubbed GEP44, this compound caused obese rats to eat up to 80% less than they would typically eat. By the end of one 16-day study, they lost an average of 12% of their weight.
But weight loss isn’t the only benefit of the peptide treatments. They also reduce blood sugar by pulling glucose into muscle tissue, where it can be used as fuel, and by converting certain cells in the pancreas into-producing cells, helping replace those that are damaged by diabetes. And there’s yet another benefit: Doyle and Heath Schmidt, Ph.D., of the University of Pennsylvania, recently reported that GEP44 reduces the craving for opioids such asin rats.
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