New-age lipid nanoparticles can directly target genetic anomalies causing various types of incurable lung diseases in humans. Here is how they work.
Delivering life-saving mRNA to mice lungs
Each nanoparticle molecule has a positively charged head and a lipid tail. The former stay linked to the negatively charged mRNA and enables it to escape the cellular structures that eat up foreign particles. Meanwhile, the lipid tail facilitates passage across the cell membrane. They designed the mRNA CRISPR/Cas9 components to cut the stop signal. Every time the mRNA did this, it triggered a measurable fluorescent signal that indicated the percentage of successful mRNA cell expressions in mice lungs.The researchers noted that foreign mRNA was expressed by about 40 percent of all lung epithelial cells only after one dose of the nanoparticle molecules. The level increased to more than 50% after two doses and 60% after three treatments.
Due to these advantages, the authors claim that their nanoparticles represent the best mRNA therapeutic approach discovered so far. They have the potential to offer treatment for various untreatable lung disorders, and therefore, they now look forward to testing them in humans.
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