'HiDEF-seq sequencing allows us to see the earliest fingerprints of molecular changes in DNA when changes are only in single strands of DNA.'
The new HiDEF-seq technique allows scientists to see the earliest fingerprints of molecular changes in DNA when the changes are only in single strands of DNA .A new study led by researchers from NYU Langone Health as well as researchers across North America and Denmark examined mutations and introduced Hairpin Duplex Enhanced Fidelity Sequencing technique.
In an ambition to advance the understanding of how mutations occur in DNA, the new method was developed. Gilad Evrony, senior study author and a core member of the Center for Human Genetics & Genomics at NYU Grossman School of Medicine“Our new HiDEF-seq sequencing technique allows us to see the earliest fingerprints of molecular changes in DNA when the changes are only in single strands of DNA.”
The study explained that most mutations begin as nucleotide mismatches or damage in one of the two strands of the DNA before becoming double-strand mutations if unrepaired or misrepaired.Conventional DNA sequencing techniques often cannot detect molecular changes in the initial stages, this new approach is aiming to resolve these initial single-strand events.
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