The Epstein-Barr virus can cause a spectrum of diseases, including a range of cancers. Emerging data now show that inhibition of a specific metabolic pathway in infected cells can diminish latent infection and therefore the risk of downstream disease.
The Epstein-Barr virus can cause a spectrum of diseases, including a range of cancers.
As yet, no drug or approved vaccination can specifically thwart EBV within the body. Now, a research group from the University of Basel and the University Hospital Basel has reported a promising starting point for putting the brakes on EBV. Their results have been published in the journalResearchers led by Professor Christoph Hess have deciphered how the immune cells infected with EBV -- the so-called B cells -- are reprogrammed.
In the paper, which has now been published, the researchers were able to show that EBV upregulates the enzyme IDO1 already months before post-transplant lymphoma is diagnosed. This finding may help to develop biomarkers for the disease."Previously, IDO1 inhibitors have been developed in the hope that they could help to treat established cancer -- which has unfortunately turned out not to be the case.
A research team hsd discovered that certain exosomes can effectively control Epstein-Barr virus-associated tumors and induce T-cell anti-tumor immunity. The novel findings provide insights into new ...
Lymphoma Viruses Infectious Diseases Virology Veterinary Medicine Biology Microbiology
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