New Alzheimer's drugs: Setting realistic expectations NeuroX
, 13% of participants receiving Leqembi experienced brain swelling and 17% of participants had brain bleeding . In the donanemab trial, brain bleeding occurred in 31.4% of participants on the drug and swelling occurred in 24% . Thankfully, in both trials, most of these adverse events did not produce significant symptoms, but in rare cases these events caused severe or catastrophic neurologic injury, including death.
per year for about 85,000 patients. This will probably spur increases to Medicare premiums, among other economic consequences for the healthcare system. Many geriatricians will get comfortable prescribing these drugs, but will our already overburdened primary care providers have the bandwidth to do the same? It's a tall order.
Yes, there are a ton of kinks to work out here, but this is an exciting start. Alzheimer's research is entering a renaissance era that will hopefully bring more groundbreaking developments. Better biomarkers to facilitate faster, easier diagnosis. More drugs that go beyond amyloid proteins for their therapeutic targets. Treatments for later-stage disease. Drugs that prevent dementia altogether.
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