Multifunctional microelectronic fibers enable wireless modulation of gut and brain neural circuits
. The ability of microelectronic fibers to deliver or sense multiple stimuli in the brain and the gut, and to interface with both organs simultaneously, sets the stage for their application in studies of gut-to-brain signaling. Future innovations in materials and fiber architectures mimicking tissue-level mechanics may extend the application scope of microelectronic fibers to peripheral organs beyond the gut.
We anticipate that with the ever-increasing repertoire of transgenic animals, multifunctional wireless fiber-based tools will provide key insights into the roles of specific cells in bidirectional communication between the peripheral organs and the brain. These tools will empower the study of the enigmatic interoceptive networks in health and disease.
for performing longer-term feeding studies with gut optogenetics provides up to 2 h of continuous operation on a single charge . The continuous operational duration of both brain and gut devices can be easily extended to several hours by adopting light-weight, high-capacity batteries . For testing the temperature recording function, the probe was placed on a hotplate with a commercial thermocouple and was left to settle for 30 s between each temperature reading.
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