In the first head-to-head comparison of two blockbuster drugs, patients taking Mounjaro lost more weight than those taking Ozempic.
In the first head-to-head comparison of two blockbuster drugs used in real-world conditions, people who took Mounjaro lost significantly more weight than their counterparts who took Ozempic — and the longer the patients kept taking the drugs, the wider the gap became. After three months of weekly injections, patients on Ozempic lost 3.6% of their body weight, on average, while those on Mounjaro lost an average of 5.9%. At the six-month mark, Ozempic patients had dropped an average of 5.
The result was a population of nearly 18,400 who were evenly split between the two drugs. Before their first medication dose, the average weight for people in both groups was 243 pounds. But it didn't take long for the two groups to diverge. After accounting for unmeasured influences that could have skewed the results, the Truveta team found that the amount of weight lost was 2.4 percentage points higher for Mounjaro patients than for Ozempic patients after three months, 4.
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