The proteins can record histories of cellular events.
Researchers from MIT developed a technique to induce cells to record the history of cellular events in a long protein chain that can be imaged using a light microscope. The technique could help understand the critical steps involved in the processes, such as memory formation, response to drug treatment, and gene expression.Studying the molecular processes within cells can provide important insights into their function and how they contribute to the overall functioning of an organ.
Using encoding, researchers designed a system to continuously produce one of the protein subunits within cells while the other subunit is only produced in response to a specific event. In this study, the V5-tagged subunit was only produced when a gene called c-fos was activated, which encodes new memories. The
To test whether this approach could be used in the brains of animals, researchers modified brain cells in mice to produce protein chains that would reveal when the animals were exposed to a particular drug. They detected this exposure by analyzing preserved tissue with a light microscope.can be used to detect various cellular events, such as cell division or the activation of protein kinases.
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