We spoke to Dr. Jeremy Carlton from TheCrick and Professor Victoria Sanz-Moreno from QMBCI about their latest research into the spread of skincancer QMUL CR_UK KingsCollegeLon
Interview conducted by Danielle Ellis, B.Sc.Jan 20 2023 Thought LeadersDr. Jeremy Carlton and Professor Victoria Sanz-MorenoWellcome Trust Senior Research Fellow/Professor of Cancer Cell BiologyKing's College London and the Francis Crick Institute/the Barts Cancer Institute In this interview, News-Medical speaks to Dr. Jeremy Carlton and Professor Victoria Sanz-Moreno about their latest research into the spread of skin cancer.
Melanoma is one of three major types of skin cancer. What are the key characteristics of melanoma? Melanoma arises from melanocytes, the pigment producing cells in the skin. Melanoma is less common than the other types of skin cancer but is far more dangerous. The reason behind its aggressive behavior is that melanoma has a high propensity to spread around the body.
How did you conduct your study, and what were your main findings? Cancer cells need to squeeze through gaps and holes in tissues during metastasis to colonize new sites. The cancer cell’s nucleus is one of the major physical barriers to this migration, and metastasizing cancer cells need to be adept at squeezing their nucleus through these gaps.
We also showed that elevating levels of LAP1 in melanoma cells made them more able to invade into collagen and into the dermis. Lastly, we found that in human melanoma samples, the levels of LAP1 could be used prognostically as a readout of disease-free survival.
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