Recent patents relating to employing metabolomic data to diagnose disease states and determine the likelihood that a patient will respond to certain treatments
, including culturing a strain of, disrupting the cell membrane and extracting metabolites. The pretreatment can ensure the repeatability and stability of the metabolomics analysis and reduce false positives in the test results.
Methods of identifying and tailoring drug therapy, including approaches to identifying metabolic consequences of drug therapy, the design of drugs based on metabolites accumulating in knockout animals and identified as potential drug transporter substrates, and the targeting of drugs and metabolites to tissue compartments on the basis of the aforementioned methods of metabolite identification.
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