Manipulation of metabolic rates by perturbing NAD(H) redox balance modulates the segmentation clock and developmental rates in murine and human cells in vitro. NBThighlight
/NADH ratio human PSM cells under control conditions or treated acutely with 10mM oxamate. Each datapoint represents the average of 3 technical replicates. Mean ±SD. n = 6. Unpaired two-sided t-test. b. Ratiometric Peredox/mCherry signal in human PSM cells cultured under control conditions or treated acutely with 10 mM oxamate. Each datapoint represents the average of >200 individual cells analyzed within a biological replicate. Mean ±SD. n = 3. Unpaired two-sided t-test, p = 8.
n denotes independent experiments. Mean ±SD. One-way ANOVA with Dunnett correction. f. HES7-Achilles oscillatory profile for human PSM cells treated with DMSO-control or 80 nM cycloheximide . n denotes independent experiments. Mean ±SEM. g. Instantaneous HES7-Achilles oscillatory period over time as calculated by Hilbert transformation for human PSM cells treated with DMSO-control or 80 nM cycloheximide . n denotes independent experiments. Mean ±SEM. h.
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