Our bodies can maintain body temperature in cold environments. However, the detailed mechanism remains unclear. Researchers elucidated the molecular mechanism by which macrophages, a type of immune cells, control heat production in brown adipose tissue to increase the body temperature in response to cold.
Our bodies can maintain body temperature in cold environments. However, the detailed mechanism remains unclear. Researchers from University of Tsukuba elucidated the molecular mechanism by which macrophages, a type of immune cells, control heat production in brown adipose tissue to increase the body temperature in response to cold.
Recently, researchers investigated the role of the transcription factor MAFB in macrophages -- an immune cell type involved in non-shivering thermogenesis within brown adipose tissue. This tissue can generate heat to increase the body temperature in response to cold, primarily regulated by the sympathetic nervous system. Therefore, the researchers bred-deficient mice and exposed them to cold conditions, monitoring their body temperature changes.
This work was supported by the Ministry of Education and Sports of Japan ; the Ministry of Education, Culture, Sports, Science and Technology of Japan under grants No. 26221004, 25860205, 23118504, 16K18398, 19K07499, and 19H00966, 23K05586, 19K07499; the Uehara Memorial Foundation; the Takeda Science Foundation; the Takamatsunomiya Cancer Foundation under grant No. 15-24724 ; and the World Premier International Research Center Initiative , MEXT, Japan.
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