Science, Space and Technology News 2024
Researchers at UCSF and UC Davis discovered a hormone, named Maternal Brain Hormone , which maintains bone strength in breastfeeding women despite calcium loss. This hormone could potentially treat osteoporosis and aid in healing fractures across different demographics. The study emphasizes the importance of including female subjects in biomedical research to uncover gender-specific biological processes.
In the new work, Ingraham and collaborators carried out an exhaustive search for this bone-building hormone and finally pinpointed CCN3 as the factor responsible in mutant females. Initially, the team was surprised by this result, as CCN3 did not fit the typical profile of a secreted hormone from neurons.
“There are some situations where highly mineralized bones are not better; they can be weaker and actually break more easily,” he explained. “But when we tested these bones, they turned out to be much stronger than usual.” “We’ve never been able to achieve this kind of mineralization and healing outcome with any other strategy,” Ambrosi said. “We’re really excited to follow it up and potentially apply CCN3 in the context of other problems, such as regrowing cartilage.”
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