Key insights into immune responses after COVID-19 vaccination in Indigenous people NatImmunol UniMelb TheDohertyInst immunology COVID19 coronavirus covid vaccine vaccination Indigenous FirstNations comorbidities
By Pooja Toshniwal PahariaJun 1 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Nature Immunology, researchers evaluated immune responses to coronavirus disease 2019 BNT162b2 messenger ribonucleic acid vaccinations among Indigenous Australian First Nations individuals by comorbidity and ethnicity.
Australian NI and FN individuals were vaccinated with the COVID-19 BNT162b2 vaccine between 2021 and 2022, and their immunity was assessed pre- and post-vaccination at different points in time. Antibody titers were measured against the SARS-CoV-2 Wuhan-Hu-1 strain and variants of concern such as Delta and Omicron.
To investigate whether the relationship between anti-SARS-CoV-2 antibodies following BNT162b2 vaccination and no galactose abundance at study initiation was associated with comorbidities or ethnicity, additional samples were obtained from 69 NI individuals, 38 of whom had diabetes or kidney disease.
The immunological disturbances were also observed among NI individuals with chronic medical conditions, indicating that they were associated with comorbid conditions instead of ethnicity. Anti-SARS-CoV-2 antibody titers increased following COVID-19 vaccination among Australian FN individuals, with almost 92% seroconversion following the second dose; however, the titers were lower than among NI individuals due to comorbidities in the FN population.
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