🎧 Listener feedback on the most important study in a decade, MONITOR-HF, a flawed paper and analysis, and the tension between pathos and logos are the topics drjohnm discusses in this week's podcast.
, an astute listener informed me that I misspoke about the PARADISE MI trial of sacubitril/valsartan. I said it was vs valsartan alone, but that is wrong; it was against ramipril. I knew that, but I got excited. So, thanks for the correction.
But Mandrola, you forgot to tell us if this was a positive trial. What was the confidence interval andThat’s the provocative thing. The ELAN authors make no such proclamation. The CI ranged from 0.44 to 1.14. They did no statistical test. There is noThe conclusions read that the incidence of the primary outcome with early vs late initiation was estimated to be from 56% lower to 14% higher. Period. It’s darn amazing.
I have to disagree when you say that colored boxes are not useful in guidelines because they oversimplify decisions. My response to this definitely majority view is first to thank the listener for listening and taking the time to write.
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