Japan officially designates today Final Fantasy 7 Day

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Japan officially designates today Final Fantasy 7 Day
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How are you celebrating?

To commemorate Final Fantasy 7's major significance as a cultural export, Japan has officially designated today—January 31—as the official Final Fantasy 7 Day, marking the anniversary of the game's PS1 release in Japan. The listing for the anniversary on thedescribes the game as"a huge hit in Japan and overseas," and hopes that"more people will enjoy FF7, which is newly developed with the latest technology as the REMAKE series".

We’re delighted to announce “Final Fantasy VII Day” has been officially registered in Japan, to commemorate the anniversary of the launch of the original game.To celebrate, here’s a special message from Yoshinori Kitase, producer of the Final Fantasy VII remake project. pic.twitter.

"With the establishment of this official anniversary day," he writes, he'll"now always remember these things, and hold them dearly in [his] heart". It would have been strange if he'd forgotten them even without the anniversary, but it's good to see the impact of the original game—and the contributions of its developers—get some well-deserved official recognition., and work is said to have begun on the third and final game that will follow it.

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Clinical impact of suboptimal RAASi therapy following an episode of hyperkalemia - BMC NephrologyClinical impact of suboptimal RAASi therapy following an episode of hyperkalemia - BMC NephrologyBackground Hyperkalemia (HK) is a barrier to optimization of renin-angiotensin-aldosterone system inhibitor (RAASi) therapy in heart failure (HF) and chronic kidney disease (CKD). We investigated cardiorenal risk associated with changes in RAASi regimen after an episode of HK in patients with HF and/or CKD. Methods This observational study utilized data from hospital records, claims, and health registers from the US (Optum’s de-identified Market Clarity Data) and Japan (Medical Data Vision). Included patients had an index episode of HK between July 2019 and September 2021 (US), or May 2020 and September 2021 (Japan), with prior diagnosis of HF or CKD (stage 3 or 4), and RAASi use. Risk of a cardiorenal composite outcome (HF emergency visit, HF hospitalization, or progression to end-stage kidney disease) was determined in patients who discontinued RAASi, down-titrated their dose by | 25%, or maintained or up-titrated their dose following the HK episode. Results A total of 15,488 and 6020 patients were included from the US and Japan, respectively. Prior to the episode of HK, 59% (US) and 27% (Japan) of patients had achieved | 50% target RAASi dose. Following the episode of HK, 33% (US) and 32% (Japan) of patients did not fill a new RAASi prescription. Risk of the cardiorenal outcome at 6 months was higher in patients who discontinued or down-titrated versus maintained or up-titrated RAASi treatment both in the US (17.5, 18.3, and 10.6%; p | 0.001) and in Japan (19.7, 20.0, and 15.1%; p | 0.001). Conclusion HK-related RAASi discontinuation or down-titration was associated with higher risk of cardiorenal events versus maintained or up-titrated RAASi.
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