Investigating the role of loops, flags and DNA tension in the spatial organization of chromosomes TUDelft nature
in the field, says Ph.D. candidate Roman Barth."In every conference presentation I attended in the past year, the basic premise was that the cohesin complex extrudes loops between correctly oriented CTCF molecules. But nobody had ever seen in detail how that happens. We have now been able to visualize the essence of this."Colleagues in Jan-Michael Peters' group at the Institute of Molecular Pathology in Vienna succeeded in making the proteins available in pure form.
The two ends of a DNA molecule were attached to a surface; the DNA and proteins were stained with a"In the data, Roman discovered that it made a difference whether the DNA strand was very loose or under tension. Without tension, cohesin often ignored the CTCF flag, even if correctly oriented, but when the DNA was under more tension, the CTCF acted as a perfect barrier.
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