Induced pluripotent stem cells show great promise for age-related macular degeneration, as revealed by recent research published in the New England Journal of Medicine.
The patients underwent a procedure where a retinal pigment epithelium patch was administered. This patch was meticulously placed in the subretinal space of one eye per patient using a specialized microsurgical tool. After placement, the cells from the patch underwentmaturation, thus replacing the damaged cells with healthy ones. Both patients experienced a substantial enhancement in their best-corrected visual acuity within 12 months.
Alas, immunosuppression or immune response are not the only risks, and one potential risk that is more common to induced pluripotent stem cells is t. iPSCs are more likely to form teratomas than other types of cells used in cell therapies. Teratomas are tumors that contain cells from multiple germ layers and can be dangerous.
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