Intranasal ketamine may be a feasible treatment alternative for people with chronic, refractory migraine who don't respond to other medications, new research shows.
Use of IN ketamine has not been studied for the treatment of chronic, treatment-refractory migraine — although it has been studied in patients withKetamine is not yet approved by the US Food and Drug Administration to treat migraine.
The majority had daily migraine, and 85% had tried more than three classes of preventive medications for migraine. They currently used a median of two medications, the most common of which was a CGRP monoclonal antibody. The most common reasons for initiating IN ketamine included an incomplete response to prior acute medications , incomplete response to prior preventive medications , and prior benefit from IV ketamine .
Among those still using ketamine during study follow-up, 82% reported that ketamine was very effective. "This real-world data suggests that ketamine is an effective option for people with medically intractable chronic migraine," said Lipton, who was not part of the study."In these very difficult to treat patients, 65% of those who started on ketamine persisted. Of those who remained on ketamine, 82% found it very effective."
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