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“Our technology amplifies the signal to express more proteins for longer while at the same time effectively eliminating the mRNA’s off-target expression,” Strand CEO Jacob Becraft PhD ’19 explains. Credit: MIT News, iStockspinout Strand Therapeutics has developed a new class of mRNA molecules that can sense where they are in the body, for more targeted and powerful treatments.
Strand is set to begin its first clinical trial in April, which is testing a self-replicating mRNA molecule’s ability to express immune signals directly from a tumor, triggering the immune system to attack and kill the tumor cells directly. It’s also being tested as a possible improvement for existing treatments to a number of solid tumors.
“That’s where I learned how lab research could be translated into spinout companies,” Becraft recalls. People have been working on cancer immunotherapy, which turns a patient’s immune system against cancer cells, for decades. Scientists in the field have developed drugs that produce some remarkable results in patients with aggressive, late-stage cancers. But most next-generation cancer immunotherapies are based on recombinant proteins that are difficult to deliver to specific targets in the body and don’t remain active for long enough to consistently create a durable response.
Strand also uses techniques like mRNA self-replication to create more durable protein expression and immune responses.
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