ASH22 High-dose MTX does not reduce CNS relapse in pediatric ALL UKALL2011
"The trial did not give us the answers we were looking for, but that's why we do randomized trials, and at least we have one clear answer, which is that high-dose methotrexate does not seem to have benefit in reducing the risk of CNS relapse," reported study investigator Ajay Vora, MSc, from Great Ormond Street Hospital in London, UK.
He was speaking at a press briefing here at the American Society of Hematology annual meeting, prior to the presentation of the data by Amy A. Kirkwood, MSc, from the University College London Cancer Institute. "Going forward, patients can be spared the risk of high-dose methotrexate without increasing their risk of recurrence in the central nervous system," she said.
Now at ASH 2022, the investigators reported outcomes from the second phase of the trial which included two randomizations: one comparing high-dose methotrexate with standard interim maintenance to reduce CNS relapse risk, and one to see whether forgoing pulses of vincristine/dexamethasone could reduce maintenance morbidity.
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