Antibiotic-resistant bacteria get extra nutrients and thrive when the drugs kill ‘good’ bacteria in the gut. New research led by scientists at Imperial College London may pave the way for improved patient risk assessment and the development of ‘microbiome therapeutics’. These innovative treatments
Imperial College London scientists found how certain bacteria resist antibiotics, pointing towards improved risk assessment and the potential for ‘microbiome therapeutics’ to restore gut balance and fight antibiotic-resistant infections.
Some antibiotics target specific bacteria, but some are ‘broad spectrum’, meaning they can kill a wide range of bacteria including both ‘bad’ pathogenic bacteria that cause infections and ‘good’ bacteria that live in our guts and help with digestion and other processes. Now, a new study shows how these resistant bacteria thrive after antibiotic use, allowing them to multiply in the gut, forming a ‘reservoir’ of disease-causing bacteria. The results were published on August 22 in the journalTo determine the effect of antibiotics, the team tested them on samples of human feces in the lab, alongside experiments in mice and lab tests of carbapenem-resistantBacteria in the gut, whether ‘good’ or ‘bad’, need nutrients to grow and reproduce.
With this information, they hope to create ‘microbiome therapeutics’. Lead researcher Dr Julie McDonald, also from the Centre for Bacterial Resistance Biology explained: “When a patient is taking antibiotics we could give them inhibitory metabolites to restrict the growth of resistant bacteria.
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