Gene Transfer Tug-of-War: Wastewater’s Role in “Superbug” Pathogen Evolution

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Gene Transfer Tug-of-War: Wastewater’s Role in “Superbug” Pathogen Evolution
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A complex interplay of factors influences the spread of superbug genes during wastewater treatment and reuse. The combination of chemical and physical stressors that bacteria face during wastewater treatment can impact the transfer of genes between them. But while certain combinations of stressor

KAUST researchers discovered that stressor combinations in wastewater treatment can influence bacterial gene transfer rates. Their findings suggest microfiltration membranes are more effective than sand filtration in reducing bacteria and eDNA concentrations, minimizing gene transfer. Credit: © 2023 KAUST; Heno Hwang

Globally, many regions are considering treated wastewater as a potentially invaluable freshwater source. “As part of the Saudi Vision 2030, water reuse and treatment rates need to be increased,” says Bothayna Al-Gashgari, a Ph.D. student in Peiying Hong’s group, who led the research. “Facilitating safe treatment and reuse is crucial,” she says. from their surroundings and integrate the functional genes it contains into their genome.

Depending on their modes of action, some combinations produced a synergistic large increase in gene-transfer rate, some had a neutral effect, while others decreased it.

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