Regenerative drug restores bone in preclinicalstudy
< 0.01. In , a graph of area of bone growth is seen for mice post–ligature but not given drug vs. mice given drug . Mice were injected with DPCA-PEG subcutaneously on days 0 and 8 after ligature placement and removal. MicroCT scans were obtained on day 15 of the experiment and on day 30 . Here, a statistical analysis of the area of bone growth is seen. Significant differences are found between the no drug control mice and DPCA-PEG-treated mice on day 15 .
In micro-CT data shows a representative mouse maxilla which had ligature removed at day 10, scanned on day 10 and then re-scanned on day 30 as compared to a representative mouse maxilla receiving ligature and DPCA-PEG drug seen on day 10 and day 30 . The level of regrowth in the drug-treated group shows an almost, if not complete, return to what is seen before the start of the experiment . In , there was no change in bone histology approximately 6 months later.
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