Science, Space and Technology News 2024
A single injection of an experimental monoclonal antibody called L9LS prevented malaria infection in children in Mali. L9LS binds to and neutralizes “sporozoites,” the form of the malaria parasite transmitted by mosquitoes that invades the liver to initiate infection. Credit: NIH
A new study reports a single dose of a malaria antibody was 77% effective in protecting children in Mali from malaria, marking a significant step in malaria prevention efforts. One injected dose of an experimental malaria monoclonal antibody was 77% effective against malaria disease in children in Mali during the country’s six-month malaria season, according to the results of a mid-stage clinical trial.
The trial in Mali took place in two parts, first to assess safety in a small number of adults and children, and then in a larger clinical efficacy trial involving 225 children. The efficacy trial took place from July 2022 to January 2023 and included healthy children 6 to 10 years of age, 75 of whom received a 300 mg dose, 75 a 150 mg dose, and 75 of whom received a placebo.
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