Nature research paper: Evolutionary histories of breast cancer and related clones
and 0.05) according to the binomial distribution determined by sequencing depth, total copy number and MCF, the mutation status was also assigned as ‘mutation_unknown’ and otherwise, the mutation status was assigned as ‘mutation_absent’.
At first, mutant allele number in a single mutant cell was calculated assuming an MCF of 100%, using the following formula:Next, adjusted TCN was determined as follows:Then, adjusted VAF was calculated by dividing MAN by aTCN.The resulting phylogenetic trees were drawn with the SNV number to infer the time course of clonal evolution by adapting the SNV accumulation rate estimated in single-cell-derived organoids.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Water in the terrestrial planet-forming zone of the PDS 70 disk - Nature Observations with the sensitive mid-infrared spectrometer MIRI on board JWST reveal the presence of a water vapour reservoir in the terrestrial plant-forming zone of the young planetary system PDS 70.
Read more »
Chemical generation of checkpoint inhibitory T cell engagers for the treatment of cancer - Nature ChemistryThree-protein conjugates, which have so far been produced using protein-engineering strategies, can now be generated using a chemical approach that enables the addition of small-molecule functionality. Checkpoint inhibitory T cell engagers (CiTEs) were assembled and shown to have enhanced in vitro potency compared to a traditional T cell engager.
Read more »
Targeted glioma therapy makes strides - Nature BiotechnologyIn Brief: Servier's successful phase 3 trial of vorasidenib in patients with a slow but usually fatal form of brain cancer, the first clinical breakthrough in the field for two decades, is likely to become a new standard of care
Read more »
Correlated insulator collapse due to quantum avalanche via in-gap ladder states - Nature CommunicationsThe microscopic mechanism of the electric-field-driven insulator-metal transition in strongly correlated systems has been debated. Here the authors present a general theory based on a quantum avalanche mediated by the formation of in-gap ladder states from multiple-phonon emission.
Read more »
Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles - Nature CommunicationsActive targeting and cytosolic delivery of therapeutic payloads are challenging in small extracellular vesicle-based drug delivery systems. Here, the authors engineer fusogen and targeting moiety co-functionalized cell-derived nanovesicles, which can selectively bind to target cells and efficiently fulfill cytosolic delivery through membrane fusion.
Read more »