A protein from Epstein-Barr virus binds to and breaks chromosome 11.
. How exactly the virus affects the development of these cancers is unclear, but tumour cells are known to be derived from infected cells that express a small subset of EBV proteins.
In fact, the only viral protein that is expressed in all types of EBV-related cancer is Epstein–Barr nuclear antigen 1 , which binds to specific sequences in the viral DNA, allowing it to persist and replicate. The possibility that this protein contributes directly to cancer has long been proposed and disputed
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