Semaglutide is an effective treatment option for weight loss, but its cost-effectiveness over the long term compared with ESG needs to be considered.
Researchers used a Markov cohort model to assess the cost-effectiveness of semaglutide vs ESG over 5 years in people with class II obesity , with the model costs based on the US healthcare system.The model simulated hypothetical patients with class II obesity who received ESG, semaglutide, or no treatment .
The model derived clinical data for the first year from two randomized clinical trials, STEP 1 and MERIT ; for the following years, data were derived from published studies and publicly available data sources.ESG led to better weight loss outcomes and added 0.06 more QALYs relative to semaglutide in the modelled patients over the 5-year time horizon; about 20% of the patients receiving semaglutide dropped out owing to medication intolerance or other reasons.
The annual price of semaglutide would need to be reduced from $13,618 to $3591 to achieve nondominance compared with ESG."The strategic choice of cost saving yet effective treatment such as ESG compared with semaglutide for specific patient groups could help alleviate the potential budget strain expected from the use of semaglutide," the authors wrote.
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