Endocrine therapy remains the mainstay of treatment in metastatic breast cancer.
, an oral SERD that shows its greatest benefits in tumors with an estrogen receptor 1 mutation — a dynamic mutation that forms over time and is associated with resistance to some forms of ET.mutations are less common when a patient is first diagnosed with breast cancer but become more common during ET. A number of other
with a variety of mechanisms of action are currently in clinical trials, both as monotherapy and in combination with a targeted agent. There really is a rich pipeline of different drugs in development for the treatment of metastatic HR+ disease.Technically, in the advanced disease setting, CDK4/6 inhibitors are approved in the first-line or pretreated setting in combination with an endocrine partner.
Can you go into more detail about the adverse effects and events associated with adjuvant treatments, particularly with CDK4/6 inhibitors?
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