Research conducted by Mass General Brigham supports clinical guidelines that indicate starting hormone therapy is safer when started close to the onset of menopause. Women have a higher likelihood of developing Alzheimer's disease (AD) compared to men, comprising two-thirds of the individuals aff
Alzheimer’s is a progressive brain disease that affects memory, thinking, and behavior. It is the most common cause of dementia among older adults and is characterized by the decline in cognitive function and the ability to perform daily activities.
Premature menopause, defined as menopause that occurs spontaneously before the age of 40 or due to surgical intervention before the age of 45, has been associated with an increased risk of AD dementia. HT improves many severe symptoms related to menopause and has been hypothesized to also prevent cognitive impairment.
The researchers used data from the Wisconsin Registry for Alzheimer’s Prevention , one of the few longitudinal studies on AD dementia that includes detailed information on menopause and HT use as well as PET neuroimaging. They analyzed PET scans from 292 cognitively unimpaired adults to determine levels of amyloid and tau in seven regions of the brain.
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